Hypertension (high blood pressure) is an elevation of blood pressure to a level that is a risk to the patient. There are two readings for blood pressure, systolic and diastolic. When the heart beats it pushes blood out into the arteries which are elastic: they balloon out a bit and gradually squeeze the blood downstream to the small vesels. As they squeeze the blood downstream the pressure falls. So the highest pressure (systolic) is at the time of the heartbeat. The lowest pressure (diastolic) is just before the next heartbeat when the arteries have almost finished squeezing. The traditional normal reading is 120 systolic over 80 diastolic, 120/80. However you may be quite healthy at 130/70 or 105/65. Normal has a wide range.
Hypertension HTN is generally accepted as a systolic BP =>140 and diastolic => 90. Risk for CVD (cardiovascular disease) starts at 115/75 so perhaps we should make that the figure to aim for. CVD risk doubles for every 20/10 increase above 115/95. A person with a BP of 135/95 is at double the risk for CVD of one whose BP is 115/75.
Causes of hypertension
Most people who have blood pressure problems do not have an obvious cause so it is termed primary or idiopathic.
Some people have hypertension secondary (secondary hypertension) to another disease. Kidney problems head this list but there are many other causes ranging from abnormal blood vessels to disorders of hormones, and tumours that produce hormones.
While the cause may be unknown there are many associated conditions. It is race related, has genetic traits and is associated with lifestyle factors such as obesity, diet and exercise.
Medications
The five main types of HTN medications are
- diuretics (water pills)
- ACE-I, ACE inhibitors, angiotensin converting enzyme inhibitors
- ARB, angiotensin 11 receptor antagonists
- CCB long acting calcium channel blockers
- (Beta-blockers) No longer first line in Britain, still accepted in US: talk with your GP about risk of diabetes.
Any of these can be used as first line therapy, and can be used in combination if there is not a good enough response to the first medication
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Complications of hypertension.
Hypertension causes
heart attacks and
strokes.
Kidney disease is related to hypertension. Kidney disease also causes hypertension.
Malignant hypertension is where hypertension causes kidney disease which worsens the hypertension etc. in a viscious circle.
Erectile dysfunction (ED) can result from hypertension and can be associated with hypertension meds.
Eye problems and
blindness. The small arteries in the eye are affected by hypertension causing haemorrhages and other damage causing problems with vision.
Hardeningof the arteries (atherosclerosis) is aggravated by hypertension. Cholesterol is laid down in arteries more easily if the artery is under pressure from hypertension. This is particularly bad where arteries split at a Y junction causing turbulence such as to the brain (the carotids) and in the pelvis to the legs (iliac arteries). Just after the Y juction there is often a thickened area called plaque which can block the arteries to the brain or legs. High blood pressure and cholesterol cause partial or total blockage of the arteries. In the case of the legs this causes
claudication which is a cramping of the leg muscles on walking or climbing a slope: and
gangrene when the blockage is total and tissue dies. In the case of the neck arteries leading to the brain this causes
strokes or
mini-strokes (TIA, transient ischaemic attack.)